The integrated test is a new method of screening for Down's syndrome, which uses measurements obtained during the first and second trimesters of pregnancy to provide a single estimate of the risk of having a pregnancy with Down's syndrome.
The integrated test is safer and more effective than currently used tests, because high detection rates can be achieved with much lower false-positive rates than existing tests, as illustrated below.
For example, using the integrated test in place of the triple test, the detection rate is higher (86% compared with 77%), and the false-positive rate is much lower (1% compared with 5%).
The screening performance of each test was based on results in the SURUSS study and Wald NJ, Rodeck C, Hackshaw AK, Rudnicka AR (2004). SURUSS in perspective. Br J Obstet Gynaecol 111, 521-531
| Triple test | Maternal age with AFP, uE3 and total hCG in the second trimester |
| Quadruple test | Maternal age with AFP, uE3, total hCG and inhibin-A in the second trimester |
| Combined test | Maternal age with nuchal translucency, PAPP-A and hCG in the first trimester |
| Integrated test | Maternal age with nuchal translucency and PAPP-A in the first trimester, and AFP, uE3, total hCG and inhibin-A in the second trimester |
| Serum Integrated test | Maternal age with PAPP-A in the first trimester, and AFP, uE3, total hCG and inhibin-A in the second trimester |
For more information on the integrated test, see : Wald NJ, Watt HC, Hackshaw AK (1999) Integrated screening for Down's syndrome based on tests performed during the first and second trimesters. N Engl J Med 341, 461-467
alpha version 7.0 is the only screening software to interpret integrated test screening results. If you are interested in using alpha with the integrated test, please contact us.
|
|
|
©Logical Medical Systems 2009